Zoledronate effect on the femur and mandible site in <i>Postn^+/+</i> and <i>Postn^−/−</i> mice.

<p>(A) Femur Bone Mineral Density (BMD). (B) Trabecular bone volume on tissue volume (BV/TV) of the distal femur. (C) Cortical Bone Volume (CtBV). (D, E, F) Biomechanical parameters obtain by three points bending test, (ultimate, UL; energy, E). (G, H) Basal bone volume fraction and alveolar bone volume fraction respectively obtains by microcomputed-tomography. (I) Mean of the internal and external <u>D</u>istance between cement-<u>E</u>namel junction and <u>A</u>lveolar bone (DEA). (J) 2D coronal illustration of the effect of zoledronate one injection per month (Zol 1M) and one injection per week (Zol 1W) in ovariectomized (OVX) <i>Postn^+/+</i> and <i>Postn^−/−</i> mice. * p<0.05, ** p<0.01, *** p<0.001 vs OVX vehicle in the respective genotype of <i>Postn^+/+</i> and <i>Postn^−/−</i>. # p<0.05, ## p<0.01, ### p<0.001 vs <i>Postn^+/+</i> in the respective treatment. $ p<0.05, $$ p<0.01 significant differences between OVX Zol 1M and OVX Zol 1W. Bars show means (± sem).