Gene ontology (GO) analysis of the time course.

<p>GO enrichment of molecular function (MF) and biological process (BP) level 5 GO terms during the time course for all DE genes (relative to the zero hour control). The value displayed is the −log₁₀(GO term FDR). GO terms with an FDR<0.01 are shown. The GO terms were clustered by their enrichment patterns using the Pearson correlation as the distance measure with average linkage. During the first day enriched GO terms include GO terms representing immune response, chemotaxis, regulation of leukocytes, blood vessel development, and angiogenesis. In the middle of the time course (3 d–14 d), GO terms for tissue development, limb morphogenesis, bone development, and forebrain development are enriched. An ectoderm development GO term is enriched at 28 days. (Detailed GO enrichment information for upregulated axolotl genes is available at <a href="http://www.axolomics.org" target="_blank">www.axolomics.org</a>). (See also <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002936#pcbi.1002936.s010" target="_blank">Table S4</a> for the −log₁₀(GO term FDR) values.)