ON01210.Na protects human bone marrow cells from radiation exposure.
- Anthony D. Kang (386819)
- Stephen C. Cosenza (386820)
- Marie Bonagura (386821)
- Manoj Manair (386822)
- M. V. Ramana Reddy (386823)
- E. Premkumar Reddy (386824)
Publication date
March 2013
DOIAbstract
<p>Human bone marrow cells were pre-treated with varying concentrations of ON01210.Na (A) or Amifostine (C) and irradiated at 2, 3, and 4 Gy to identify the optimum dose of drug for radioprotection. Varying doses of radiation were used on human bone marrow cells that were pre-treated with 10 uM ON01210.Na (B) or 250 uM Amifostine (D) to calculate the dose reduction factor (DRF). ON01210.Na protected human bone marrow cells with a calculated DRF value of 1.6.</p
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