Examples of agents that potentiated production of IL-17A and IL-17F in BT co-cultures.

<p>Profiles of BW 245C (0.37–10 μM; A), LPS (0.1–100 ng/ml; B), or HKLM (10–10,000 U/ml; C) added to BT co-cultures stimulated with α-IgM and SAg for three days. BW245C and LPS enhance IL-17A and IL-6 production, while LPS also stimulates IL-17F, secreted IgG, IL-6, and TNFα. HKLM stimulates IL-17F more potently than IL-17A. Data are presented as the log₁₀ ratio of treated stimulated cells compared to control stimulated cells. The gray area above and below the y-axis origin indicates the 95% significance envelope for control samples based on historical data.