Macrophage uptake of ¹²⁵I-LDL is non-saturable.

<p>A. LDLR−/− macrophages were incubated with 1 mg/ml of LDL for 0–24 h and cholesterol accumulation was then assessed. B. LDLR−/− macrophages were incubated 24 h with increasing concentrations of ¹²⁵I-LDL, and then ¹²⁵I-LDL uptake was assessed. Uptake values represent the sum of cell-associated and degraded ¹²⁵I-LDL. The range of cell-associated and degraded ¹²⁵I-LDL was 7–13% and 87–93%, respectively.