Sequence comparison of <i>PIGR</i> haplotypes.

<p>(<b>A</b>) Variant positions at which the corresponding pair of <i>PIGR</i> haplotypes <b><i>D</i></b>iffer (upper line; “D”), or are the <b><i>S</i></b>ame (lower line; “S”). The positions of the <i>PIGR</i> exons are marked by the transparent gray boxes. (B) Schematic representation of the three major <i>PIGR</i> haplotypes with indication of the positions at which they differ or not. Within the body of the <i>PIGR</i> gene, haplotype I is appears as a recombinant between haplotype II and III, which differ on average every 109 nucleotides. Upstream of the gene, the three haplotypes differ on average every ∼200 nculeotides.