Genetic network of genes up-regulated independently of DNA-PK following heat stress.

<p>(a) Illustrative Venn diagram of up-regulated genes in siLuc- and siDNA-PKcs-transfected cells after exposure to heat stress; (b) Common up-regulated genes in both siLuc- and siDNA-PKcs-transfected cells exposed to heat stress (Group 1); the genetic network is displayed graphically as nodes (genes) and edges (the biological relationships between genes). The node color indicates the expression level of the respective gene. Nodes and edges are displayed in various shapes and labels that represent the functional classes of genes and the nature of the relationship among nodes, respectively. This network shows that HSP genes were not associated with DNA-PK status and that JUN-related genes were up-regulated in response to heat-induced cell damage.