Rapamycin improved recognition memory in rats subjected to SE.

<p>The novel object recognition test was used to assess recognition memory in sham and SE rats treated with rapamycin (Rap) or vehicle (Veh). Rats were allowed to explore 2 objects for 5 minutes during the training phase. Two hours later, the rats were re-exposed to a previously explored object (familiar object) and a novel object, and exploration time of each object was evaluated. Sham+Veh and Sham+Rap rats spent significantly more time exploring the novel object than the familiar object. SE+Veh rats spent a similar amount of time exploring both objects. This deficit was reversed by rapamycin in the SE+Rap group. **<i>P<</i>0.001, ANOVA with Tukey’s <i>post hoc</i> test; n = 7−11. Error bars = SEM.