Proposed model for GCS-derived ganglioside GD1a and GM1 regulation of hypothalamic leptin signaling and energy homeostasis.
- Viola Nordström (388258)
- Monja Willershäuser (388259)
- Silke Herzer (388260)
- Jan Rozman (149181)
- Oliver von Bohlen und Halbach (357563)
- Sascha Meldner (388261)
- Ulrike Rothermel (388262)
- Sylvia Kaden (388263)
- Fabian C. Roth (388264)
- Clemens Waldeck (388265)
- Norbert Gretz (14081)
- Martin Hrabě de Angelis (2579524)
- Andreas Draguhn (52446)
- Martin Klingenspor (68144)
- Hermann-Josef Gröne (270989)
- Richard Jennemann (388266)
Publication date
March 2013
DOIAbstract
<p>(A) GCS-derived gangliosides form complexes with ObR, thereby facilitating leptin-dependent Jak and Stat3 phosphorylation, and formation of PIP3. These pathways are crucial contributors to regulation of energy homeostasis. (B) In obese <i>Ugcg</i><sup>f/f//CamKCreERT2</sup> mice, ObR signal transduction is abolished in GCS-depleted neurons.</p
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