A schematic representation of the effect of anti-LRP/LR specific antibodies on angiogenic tube formation.

<p>(A) The administration of anti-LRP/LR antibody W3, to HUVE cells which had established tubular structures on Matrigel^™, inhibited further degradation of the basement membrane, a requirement for tube formation. This halted the development for additional tubular structures. Moreover, the antibody also bound to existing tubes and thereby blocked the interaction between LRP/LR and Laminin-1, hence resulting in (B) the reversal of tube formation and cells were consequently observed as single cells on the Matrigel^™.