<p>A) Western analyses of anterior frontal cortex (Ant-Fc), ventro-lateral posterior cortex (V-L-post-FC), posterior frontal cortex (post-FC), cerebellum (CB). B) Double immunofluorescence labeling of PINCH (green) and hp-Tau (red), co-localization (yellow) in hippocampal tissue from a wild-type mouse and the Tau-Tg mouse and respectively.</p
<p>(A) Cortical and (B) hippocampal extracts were prepared from two different 3 and 6-week-old wt an...
<div><p>Stem cell (SC) lines that capture the genetics of disease susceptibility provide new researc...
<p>HRD1 and SEL1L levels in the cerebral cortex of Tg2576 (hemizygous human Swedish double-mutated A...
<p>A) Representative Western blot showing PINCH, soluble hp-Tau (s262) and total Tau (HT7) in age-ma...
Heterozygous hTau mice were used for the study of tau seeding. These mice express the six human tau ...
<p>Frozen mouse brain sections (10 μm) were subjected to Immuno-FISH as described in the Materials a...
The early occurrence of brainstem-related symptoms, e.g. gait and balance impairment, apathy and dep...
(A) H&E staining of sagittal brain sections of mice shows neuronal loss in the hippocampus of transg...
<p>Forebrains were stained with antibodies against total Tau (DA9, A, B, C), pSer202 (CP13; D, E, F)...
<p>Top panels illustrate <i>p</i>-tau IR in the hippocampus of 9 month old (<b>A</b> vs <b>B)</b> an...
The rTg4510 mouse overexpresses an inducible human mutant tau (TauP301L) selectively in the forebrai...
<p>A) Tau phosphorylation intensities were compared in the cortex of young (3 month-old) wild-type (...
Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerati...
Acknowledgements: This work was supported by the Electron Microscopy Facility of the MRC Laboratory ...
<p>(<b>A–J</b>) Detailed graphs of the cortex and hippocampus that show the age-dependent intracellu...
<p>(A) Cortical and (B) hippocampal extracts were prepared from two different 3 and 6-week-old wt an...
<div><p>Stem cell (SC) lines that capture the genetics of disease susceptibility provide new researc...
<p>HRD1 and SEL1L levels in the cerebral cortex of Tg2576 (hemizygous human Swedish double-mutated A...
<p>A) Representative Western blot showing PINCH, soluble hp-Tau (s262) and total Tau (HT7) in age-ma...
Heterozygous hTau mice were used for the study of tau seeding. These mice express the six human tau ...
<p>Frozen mouse brain sections (10 μm) were subjected to Immuno-FISH as described in the Materials a...
The early occurrence of brainstem-related symptoms, e.g. gait and balance impairment, apathy and dep...
(A) H&E staining of sagittal brain sections of mice shows neuronal loss in the hippocampus of transg...
<p>Forebrains were stained with antibodies against total Tau (DA9, A, B, C), pSer202 (CP13; D, E, F)...
<p>Top panels illustrate <i>p</i>-tau IR in the hippocampus of 9 month old (<b>A</b> vs <b>B)</b> an...
The rTg4510 mouse overexpresses an inducible human mutant tau (TauP301L) selectively in the forebrai...
<p>A) Tau phosphorylation intensities were compared in the cortex of young (3 month-old) wild-type (...
Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerati...
Acknowledgements: This work was supported by the Electron Microscopy Facility of the MRC Laboratory ...
<p>(<b>A–J</b>) Detailed graphs of the cortex and hippocampus that show the age-dependent intracellu...
<p>(A) Cortical and (B) hippocampal extracts were prepared from two different 3 and 6-week-old wt an...
<div><p>Stem cell (SC) lines that capture the genetics of disease susceptibility provide new researc...
<p>HRD1 and SEL1L levels in the cerebral cortex of Tg2576 (hemizygous human Swedish double-mutated A...