Distribution and pharmacokinetic profile of [¹⁸F]paroxetine ([¹⁸F]-1) from MR-PET imaging in non-human primates.

<p>(A) Summed images from 5–50 min of the dynamic PET collected following injection of <b>[¹⁸F]-1</b>. The images are fused with a structural (T1 weighted) MR image. Although <b>[¹⁸F]-1</b> is a potent and selective ligand for the serotonin transporter (SERT), the observed binding does not match the distribution of SERT. This is indicative of high non-specific binding. The images highlight the overall high blood-brain-barrier penetration of <b>[¹⁸F]-1</b> and heterogeneity of binding observed. (B) Whole-brain average time-activity curves from <b>[¹⁸F]-1</b> from baseline and pretreatment (citalopram) studies.