The gene expression of several genes that are modulated differently in DD patient fibroblasts compared to control fibroblasts.

<p>(A) <i>FGF9</i>, (B) <i>KRT34</i>, (C) <i>THBS4</i>, (D) <i>VCAM1</i> and (E) <i>FMOD</i>. Relative PSR fluorescence (y-axis) is plotted for each PSR (points along x-axis). Samples were either from DD fibroblast (blue) or skin fibroblasts from patients without DD (red). PSRs are oriented 5′ to 3′ across the gene from left to right on the x-axis. Relative expression levels are plotted on a log₂ scale. Arrow represents a PSR region that was used for subsequent PCR validation. Four separate samples from different individuals were used for the DD cohort and six different individuals' samples for control fibroblasts. Error bars = SEM. Actual PSR numbers are shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0059056#pone.0059056.s001" target="_blank">Figure S1</a>.