Results from the COPD proteomics data analysis using GSEA, SPIA, and DEAP (<i>Methods</i><i>: Biological data</i>).

<p>An <i>S</i> and <i>M</i> indicate pathway differential expression significance of <i>p</i>< = 0.05 and marginal significance of <i>p</i>< = 0.1, respectively. Italic text indicates previously discovered associations between the pathway and COPD. Non-italic text indicates no known associations between the pathway and COPD.</p>*<p>Arginine and pyrimidine are used therapeutically to treat COPD. Specific p-values are found in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002967#pcbi.1002967.s016" target="_blank">Table S6</a>.