Cumulative distributions of resting and active period durations in clock gene-deficient mice.

<p>(<b>a</b>)–(<b>c</b>) Comparison of group-averaged cumulative distributions of rescaled resting period durations between the WT mice and (<b>a</b>) <i>mPer2^Brdm1</i>, (<b>b</b>) <i>Clock/Clock</i>, and (<b>c</b>) <i>Bmal1⁻</i>^/− mice, where a non-zero mean is used as the threshold value. Error bars indicate standard error of the mean. Straight lines are eye guides with the group mean parameter values (WT, ; <i>mPer2^Brdm1</i>, ; <i>Clock/Clock</i>: ; <i>Bmal1</i>^−/−, ). (<b>d</b>)–(<b>f</b>) Group-averaged cumulative distributions of active period durations. The broken (WT mice) and solid (deficient mice) curves are stretched exponential functions with the group mean parameter values shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058884#pone-0058884-t002" target="_blank">Table 2</a>. Note that the resting distributions are shifted along the vertical axis to take the same value at , and the distributions are plotted with wider bins () for the purpose of illustration. The results for the WT and <i>mPer2^Brdm1</i> mice are reproduced from our previous study <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058884#pone.0058884-Nakamura1" target="_blank">[10]</a>.