Swelling and CFU Reduction after RIF-STR treatment.

<p>After 3 days of RIF-STR (RS) treatment (day 27 after infection), swelling averaged grade 1, and then declined to 0.61±0.33, 0.27±0.18, 0.14±0.18, 0, 0.06±0.17, and 0 on days 34, 40, 48, 44, 63, and 78, respectively. CFU also declined from 6.02±0.09 log₁₀ on day 27, and then 3.83±0.56 log₁₀, 2.82±0.49 log₁₀, 0.52±0.45 log₁₀, 0.2±0.35 log₁₀, 0, and 0 on days 34, 40, 48, 44, 63, and 78, respectively. For comparison, CFU per footpad for untreated controls (black line) show the impact of antibiotic treatment on bacterial burden. Data based on 3 mice per group per time point.