IL-12 promotes polyfunctional responses by HBV-specific T cells.

<p>a) Representative FACS plot showing IFN-γ and TNF-α production after restimulation of CD8 T cells with HBV-derived peptides. The summary data show the percentage of IFN-γ/TNF-α double positive CD8 T cells out of all those producing either cytokine. b) Frequency of CD107a and c) IL-2 positive CD8 T cells upon restimulation with HBV-derived peptide, cells were cultured in the presence or absence of IL-12. d) Expression levels of the pro-apoptotic molecule Bim in HBV-specific <b>(</b>IFN-γ+) CD8 T cells after culture in the presence or absence of IL-12; mean fluorescence intensity (MFI) is shown. All experiments were analysed after 10 day culture.