Glycan array analysis of viruses that showed no replication or replication in the lung explants.

<p>Binding signal of viruses that have a high degree of replication (OK483/H3N2, swG07/H1N1, 99/H9N2, 09/H9N2 NL219/H7N7, NL33/H7N7,and ck/H7N7 and those that have a low degree of replication (309/H3N2, OK5342/H3N2 and swHK99/H1N1) in the human ex vivo lung. Different types of sialoglycans on the array (x-axis) present in the human respiratory tract are indicated by numbers referred to in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003223#ppat-1003223-g005" target="_blank">Figure 5</a> and shading/hatch refers to whether the glycans are N-linked or O-linked. Vertical bars denote mean binding signal (fluorescence intensity). A is a human H3N2 virus, B is a swine isolated H1N1 virus, C and D are human isolated H9N2 viruses and E–G are H7N7 viruses. H and I are human H3N2 viruses and J is a swine H1N1 isolated virus.