<p>rAd-proinsulin-B10 particles or saline (Control) was delivered by I.V. injection. Serum samples were obtained at 24 h and 48 h post-transduction and saliva, parotid gland (PTG), submandibular gland (SMG), liver and spleen tissues were collected at the conclusion of the experiment (48 h). (<b>a</b>) Blood glucose (mg/dl) measurements at 24 h and 48 h post-transduction. No statistical difference in glucose levels was observed between groups (ANOVA) (<b>b</b>) Sera, saliva and protein lysates from PTG and SMG were assayed for hProinsulin (pM) by ELISA. (<b>c</b>) QPCR analysis of rAd vector genome tissue distribution at the conclusion of the experiment. Data are expressed as rAd genome copies detected in 100 ng of tissue genomic DNA. For al...
Transfer of naked plasmid with insulin precursor DIVA into skeletal muscle of streptozotocin (STZ)-i...
AbstractTransgenic mice expressing either human proinsulin cDNA or mutated proinsulin cDNA in the li...
<p>A) Blood glucose levels in NOD mice measured every two weeks (n = 5) showing a significant rise i...
<p>rAd-proinsulin-B10 or saline (Control) was delivered to both SMG by retroductal infusion. Serum s...
<p>rAd-proinsulin-B10 or saline (Control) was delivered to both PTGs of non-diabetic mice by retrodu...
<p>(<b>a, b</b>) HEK293 cells were transduced with rAd-proinsulin-WT (<b>a</b>) or –B10 (<b>b</b>) a...
Adenovirus (Ad) mediated expression of therapeutic proteins from salivary glands can result in the d...
<div><p>Adenovirus (Ad) mediated expression of therapeutic proteins from salivary glands can result ...
<p>Sections of paraffin embedded pancreata were immunostained with anti-insulin antibodies (red), an...
We have used transgenic mice to study immune tolerance to autologous, non-MHC encoded proteins that ...
<p>A Gateway ready arrayed library of 248 factors (left, top panel) were transferred into the transp...
AbstractThe blood concentration of intact proinsulin, but not total proinsulin, has been suggested t...
<p><i>(A)</i> Concentration of PYY<sub>3-36</sub> in plasma during fasting and after feeding. <i>(B)...
OBJECTIVE—Endoplasmic reticulum (ER) stress has been de-scribed in pancreatic b-cells after onset of...
Anadenoviral (Ad) vector that expresses bioactive glucagon-like peptide 1 (GLP-1) was generated, and...
Transfer of naked plasmid with insulin precursor DIVA into skeletal muscle of streptozotocin (STZ)-i...
AbstractTransgenic mice expressing either human proinsulin cDNA or mutated proinsulin cDNA in the li...
<p>A) Blood glucose levels in NOD mice measured every two weeks (n = 5) showing a significant rise i...
<p>rAd-proinsulin-B10 or saline (Control) was delivered to both SMG by retroductal infusion. Serum s...
<p>rAd-proinsulin-B10 or saline (Control) was delivered to both PTGs of non-diabetic mice by retrodu...
<p>(<b>a, b</b>) HEK293 cells were transduced with rAd-proinsulin-WT (<b>a</b>) or –B10 (<b>b</b>) a...
Adenovirus (Ad) mediated expression of therapeutic proteins from salivary glands can result in the d...
<div><p>Adenovirus (Ad) mediated expression of therapeutic proteins from salivary glands can result ...
<p>Sections of paraffin embedded pancreata were immunostained with anti-insulin antibodies (red), an...
We have used transgenic mice to study immune tolerance to autologous, non-MHC encoded proteins that ...
<p>A Gateway ready arrayed library of 248 factors (left, top panel) were transferred into the transp...
AbstractThe blood concentration of intact proinsulin, but not total proinsulin, has been suggested t...
<p><i>(A)</i> Concentration of PYY<sub>3-36</sub> in plasma during fasting and after feeding. <i>(B)...
OBJECTIVE—Endoplasmic reticulum (ER) stress has been de-scribed in pancreatic b-cells after onset of...
Anadenoviral (Ad) vector that expresses bioactive glucagon-like peptide 1 (GLP-1) was generated, and...
Transfer of naked plasmid with insulin precursor DIVA into skeletal muscle of streptozotocin (STZ)-i...
AbstractTransgenic mice expressing either human proinsulin cDNA or mutated proinsulin cDNA in the li...
<p>A) Blood glucose levels in NOD mice measured every two weeks (n = 5) showing a significant rise i...