<i>meis1.1</i> is down regulated in <i>hoxd4a</i> morphants and <i>meis1.1</i> mRNA rescues hematopoietic and vasculogenic gene expression in <i>hoxd4a</i> morphants.

<p>Expression of <i>meis1.1</i> in control (A), morphant (B) and <i>hoxd4a</i>-rescuant (C) embryos at 26–28 hpf. (D–I) At 13 hpf, normal expression of <i>gata1</i>, <i>scl1</i> and <i>fli1</i> (D–F) is reduced in <i>hoxd4a</i> morphants (G–I), but rescued upon co-injection with capped mRNA for <i>meis1.1</i> (J–L). (M,N) Rescue of vascular patterning in <i>hoxd4a</i> morphants by co-injection with capped mRNA for <i>meis1.1</i> as visualized in Tg(fli1:EGFP) transgenics at 48 hpf (M) and by alkaline phosphatase staining at 72 hpf (N). Scale bars equal 100 µm.