Effect of leptin and adiponectin on global apoptosis and on caspase activation in HUVEC cells.

<p><b>A.</b> HUVECs were cultured in the presence of increasing concentrations of human recombinant leptin (10 to 1,000 ng/mL) for 72 in a medium without VEGF and bFGF (n = 3). <b>B.</b> HUVECs were cultured in the presence of increasing concentrations of human recombinant adiponectin (100 to 10,000 ng/mL) for 72 hours in a complete medium (n = 3). Data are presented as mean ± SEM *p<0.05 vs control. <b>C.</b> HUVECs were cultured in the presence of increasing concentrations of human recombinant leptin (10 to 1,000 ng/mL) for 72 in a medium without VEGF and bFGF (n = 1) <b>D.</b> HUVECs were cultured in the presence of increasing concentrations of human recombinant adiponectin (100 to 10,000 ng/mL) for 72 hours in a complete medium (n = 1).