Resveratrol did not protect phosphorylated EGFR from endogenous phosphatases, led to EGFR accumulation in the keratinocyte membranes, and induced its cytosolic degradation.

<p>Western blot analysis of the plasma membrane fraction, where cadherin was used as a loading control (<b>A</b>) and of the cytosolic fraction (<b>C</b>). After 24h treatment with resveratrol (Resv), keratinocytes were stimulated with TGFα (50 ng/ml) for 10 minutes. Then, 2 µM PD168393 (PD16) were added to the medium for further 10 minutes. (<b>B</b>, <b>D</b>) Quantification of Western blot bands by densitometry. *<i>P</i><0.05 and ^§<i>P</i><0.01 <i>versus</i> untreated controls.