<p>a) Changes in the number of cells in each cell population over time, averaged over 50 simulations and b) changes in the concentration levels of the secreted molecules over time, also averaged over 50 simulations. In c) NCD over time between two consecutive states of one simulation and d) changes over time in the NCD between the same state taken from two distinct simulations. The average of 50 simulations is shown with the 5th percentile confidence interval. The major changes in NCD in (c) co-occur with the events in a) and b). There is a clear trend of divergence in d) as the distances between trajectories from different runs increase over time.</p
Molecular dynamics simulations of the RN24 peptide, which includes a diverse set of structurally he...
<p>(a) Time course of root mean square deviations (RMSDs) of wild-type CycT1 (left) and CycT1 mutant...
<p>The variance of the MSTd population was averaged across the template space over different runs of...
<p><b>A</b>) Average fitness of the total population due to experiments (black dots), stochastic sim...
<p>Shown are six individual lineage A) , B) and C) cell levels over time, with means superimposed;...
<p>The system size is and the mutation rate is . The simulation was carried out for time steps. Ea...
<p>Shown are levels of A) , , , and B) , , in a single niche lineage over the full simulation time....
<p>The co-evolutionary time-dynamics for the level of PI, solicitation allele frequencies and sensit...
<p><b>A</b>) Transitions between the three types considered, wild types (W), resistant types without...
<p>(A) Snapshot of the simulation with periodically reversing agents (<i>η</i> = 0.24) at 180 min of...
<p>Parameter choices are , , and simulations were performed on a lattice. Trajectories are average...
<p>(A) 1200 CTL are present at the beginning of the simulation. (B) 400 CTL are present at the begin...
<p>(A,B) Simulations binned on the time of reaching high fitness (0.85), when adapting for the first...
<p>After approximately 2 years post-PHI, diversity grows linearly in the latent reservoir (blue soli...
<p> is the fraction of time points (between 300 min and 700 min) at which more than 95% or less than...
Molecular dynamics simulations of the RN24 peptide, which includes a diverse set of structurally he...
<p>(a) Time course of root mean square deviations (RMSDs) of wild-type CycT1 (left) and CycT1 mutant...
<p>The variance of the MSTd population was averaged across the template space over different runs of...
<p><b>A</b>) Average fitness of the total population due to experiments (black dots), stochastic sim...
<p>Shown are six individual lineage A) , B) and C) cell levels over time, with means superimposed;...
<p>The system size is and the mutation rate is . The simulation was carried out for time steps. Ea...
<p>Shown are levels of A) , , , and B) , , in a single niche lineage over the full simulation time....
<p>The co-evolutionary time-dynamics for the level of PI, solicitation allele frequencies and sensit...
<p><b>A</b>) Transitions between the three types considered, wild types (W), resistant types without...
<p>(A) Snapshot of the simulation with periodically reversing agents (<i>η</i> = 0.24) at 180 min of...
<p>Parameter choices are , , and simulations were performed on a lattice. Trajectories are average...
<p>(A) 1200 CTL are present at the beginning of the simulation. (B) 400 CTL are present at the begin...
<p>(A,B) Simulations binned on the time of reaching high fitness (0.85), when adapting for the first...
<p>After approximately 2 years post-PHI, diversity grows linearly in the latent reservoir (blue soli...
<p> is the fraction of time points (between 300 min and 700 min) at which more than 95% or less than...
Molecular dynamics simulations of the RN24 peptide, which includes a diverse set of structurally he...
<p>(a) Time course of root mean square deviations (RMSDs) of wild-type CycT1 (left) and CycT1 mutant...
<p>The variance of the MSTd population was averaged across the template space over different runs of...