NSE-apoE4 and apoE4-KI, but not GFAP-apoE4, mice have reduced dendritic spine density in the entorhinal cortex at 19–21 months of age.

<p>(<i>A</i>) Representative images of dendrites with spines from the entorhinal cortex of NSE-apoE3, NSE-apoE4, apoE3-KI, apoE4-KI, GFAP-apoE3, or GFAP-apoE4 mouse brains. (<i>B</i>) Quantification of total spine density in the entorhinal cortex, combining AO+BS spines. (<i>C</i>) Number of AO and BS spines in the CA1. Values are mean ± SEM, n = 20–25 neurons from 3–5 mice for each group. *<i>p</i><0.05, **<i>p</i><0.01, ***<i>p</i><0.001.