<p>Breakdown, by mechanism of action, of top 24 most effective simulated drugs (those scoring 0.9 or higher). Y axis indicates fraction of top 24 drugs having the quantitative alteration shown for the given mechanism (e.g., slightly greater than 60% of the top drugs had an AMPA τ<sub>2</sub> value of 1 ms). Titles correspond to mechanisms of action described in text. Baseline value for AMPA τ<sub>2</sub> is 3 ms. b/l = baseline.</p
<p>Corresponding figures are indicated in brackets.</p><p>Summary of tested physiological reproducib...
<p>The difference of Qmax between comparisons was calculated as mean difference (MD) and MD above 0 ...
Heatmap of significant Spearman correlations between simulated and experimental drug response data. ...
*<p>p < 0.001</p><p>Using the wellness metric (see text), as the outcome variable, 97 of 1,500 simul...
<p>Note: The numbers in parentheses represent the results in LNs and those not in parentheses repres...
The names of the drugs previously shown to extend lifespan in animal models are in bold. The numeric...
X-axes denote the magnitude with which control-group parameters were perturbed to establish a compar...
<p>Note: The numbers in parentheses represent the results in LNs and those not in parentheses repres...
The performance of a drug in a clinical trial setting often does not reflect its effect in daily cli...
(A) The extended Patlak model, now including the effects of the drug on the transport rates. (B) The...
<p><b>A:</b> Effect of enhancing and reducing the magnitude of the prediction error on learned rewar...
<p>(a) epinephrine; (b) pindolol; (c) salbutamol; and (d) salmeterol. The spare receptors were norma...
<p>Simulated model profiles with changes in: A) Apoptosis duration, <i>T<sub>A</sub></i>, B) Maximum...
Using defined critical PK/PD exposure values, a population of 1,000 simulated patients were defined ...
Objectives: A major challenge in drug discovery and development is the prediction, in a strictly qua...
<p>Corresponding figures are indicated in brackets.</p><p>Summary of tested physiological reproducib...
<p>The difference of Qmax between comparisons was calculated as mean difference (MD) and MD above 0 ...
Heatmap of significant Spearman correlations between simulated and experimental drug response data. ...
*<p>p < 0.001</p><p>Using the wellness metric (see text), as the outcome variable, 97 of 1,500 simul...
<p>Note: The numbers in parentheses represent the results in LNs and those not in parentheses repres...
The names of the drugs previously shown to extend lifespan in animal models are in bold. The numeric...
X-axes denote the magnitude with which control-group parameters were perturbed to establish a compar...
<p>Note: The numbers in parentheses represent the results in LNs and those not in parentheses repres...
The performance of a drug in a clinical trial setting often does not reflect its effect in daily cli...
(A) The extended Patlak model, now including the effects of the drug on the transport rates. (B) The...
<p><b>A:</b> Effect of enhancing and reducing the magnitude of the prediction error on learned rewar...
<p>(a) epinephrine; (b) pindolol; (c) salbutamol; and (d) salmeterol. The spare receptors were norma...
<p>Simulated model profiles with changes in: A) Apoptosis duration, <i>T<sub>A</sub></i>, B) Maximum...
Using defined critical PK/PD exposure values, a population of 1,000 simulated patients were defined ...
Objectives: A major challenge in drug discovery and development is the prediction, in a strictly qua...
<p>Corresponding figures are indicated in brackets.</p><p>Summary of tested physiological reproducib...
<p>The difference of Qmax between comparisons was calculated as mean difference (MD) and MD above 0 ...
Heatmap of significant Spearman correlations between simulated and experimental drug response data. ...