Cognitive impairment in <i>Myk</i>/+ mice.

<p>(A) Fear conditioning with 1.0-mA footshock. Mean freezing levels (± SEM) of <i>Myk</i>/+ (<i>n = </i>24) and +/+ (<i>n = </i>25) mice at baseline, during training, and in the contextual and cued conditioning tests. There were significant main effects of genotype on freezing in the context test (<i>F</i>_1,48 = 8.52, <i>P = </i>0.005) and in the cue test during presentation of the auditory tone (CS; <i>F</i>_1,48 = 6.20, <i>P = </i>0.016). (B) Conditioned taste aversion. Mean (± SEM) CS consumption scores (intake of saccharin/total fluid) 24 h following pairing with LiCl or saline treatment in <i>Myk</i>/+ and +/+ mice. There were significant main effects of genotype (<i>F</i>_1,47 = 6.51, <i>P = </i>0.014), treatment (<i>F</i>_1,47 = 48.12, <i>P = </i>0.0001), and genotype x treatment interaction (<i>F</i>_1,47 = 4.09, <i>P = </i>0.049). *<i>P<</i>0.05; ***<i>P<</i>0.001; ****<i>P<</i>0.0001 versus +/+ mice.