Summary of inbreeding coefficient estimates across cohorts, and association testing.

<p>For each case and control group we present the average the estimated inbreeding coefficient and the number of individuals with inbreeding coefficients above a specified threshold. The last column indicates the total number of individuals in each group. The bottom two rows indicate the results of an association test between inbreeding and case/control status using either a categorical variable as a definition of inbreeding status (<i>F</i>>0.5%, <i>F</i>>1.6%, and <i>F</i>>6.25%) or using the inbreeding coefficient as a continuous variable (“All <i>F</i>”).