Intratumour genome diversity by SNP array analysis.

<p><i>(A–C)</i> Representative examples of relative DNA content estimates from mBAF data for allelic imbalances in three NBs. The prevalence (DNA content) of each allelic imbalance is given as abnormality content (AC) plotted on the y-axis, while the type of aberration is specified along the x-axis. Red and green lines indicate maximum and minimum estimated DNA content. Segments affected by aberrations are specified according to cytogenetic nomenclature;+and - indicate gain and loss of a single copy, respectively. ITCC35 is a Type 1 NB exhibiting trisomy for seven chromosomes and monosomy for one, all of which are present at similar prevalence. ITCC130 is a type 2A tumour with multiple structural and numerical changes present at different prevalence levels, including 1p deletion, 11q deletion and 17q duplication. ITCC174 is a type 2B <i>MYCN</i> amplified NB with structural aberrations confined to three distinct prevalence levels. The prevalence span (<i>s</i>) of each case is denoted on the y axis. <i>(D)</i> Mean prevalence spans according to clinical-genetic type and <i>(E)</i> aberration type (NUM, numerical/whole chromosome changes; STR, structural changes); errors bars denote standard deviations.