TIM-3 expression on CD8 T cells of HIV-1-infected individuals.

<p>A) TIM-3 and PD-1 expression on CD8 T cells from HIV-1-infected individuals. The percentage of positive cells in the CD45RA⁺ and CD45RA⁻ subsets are indicated. Correct assessment of TIM-3 and PD-1 positive cells was ensured by isotype control antibody (IgG-PE) staining for each sample. Representative samples from a suppressed (upper panels) and from viremic patients (middle and lower panels) are shown. B) Percentage of TIM-3⁺ (left graph) and PD-1⁺ (right graph) CD8 T cells from suppressed (S) and viremic (V) patients and from healthy individuals (H) are shown. Bars indicate median percentage. C) Percentage of TIM-3⁺ (left graph) and PD-1⁺ (right graph) CD8 cells in the CD45RA⁺ and CD45RA⁻ subsets. D) Percentage of TIM-3⁺ (left graph) and PD-1⁺ (right graph) CD8 cells in the CD57⁺ and CD57⁻ subset.