LKB1 is required for the progression of positive selection and maturation of T cells.

<p>(A) Thymi from LKB1^fl/fl CD4Cre^neg and CD4Cre^pos mice were analysed for the co-expression of TCRβ and CD69 using flow cytometry as previously described <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060217#pone.0060217-Tamas1" target="_blank">[6]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060217#pone.0060217-Cao1" target="_blank">[7]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060217#pone.0060217-Lesourne1" target="_blank">[13]</a>. (B) Flow cytometric analysis of TCRβ^high cells stained for the surface expression of CD24 (heat stable antigen) and CD62L (L-selectin). Data shown are representative of at least three mice.