Functional imaging results for the training session.

<p>Functional results are displayed at p_uncorrected<0.001 over the mean structural image of all subjects. In the insets, whiskers represent SEM. CN: Caudate Nucleus, HC: Hippocampus. A- Linear modulation of brain responses by performance consistency. Caudate nucleus responses increased during training in parallel to performance reproducibility. The dynamics of caudate activity follows a similar non-linear pattern as performance consistency during training. The functional connectivity between the caudate nucleus and frontal areas is proportional to performance variability during training <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0059490#pone.0059490-Albouy1" target="_blank">[2]</a>. B- Regression analysis between cerebral areas functionally connected with the caudate nucleus, in proportion to performance variability and gain in performance in the SG. Left panel: The strength of the functional connectivity (competitive interaction) between the caudate nucleus and hippocampo-cortical areas is correlated with the subsequent gains in performance on the learned sequence in the SG. Right panel: Regression plot of the strength of the functional connectivity (competitive interaction) between the caudate nucleus and the hippocampus related to performance variability against the gains in performance in the SG (block duration (s)) on the learned sequence. Each data point represents a single subject of the SG.