The levels of COX-2 mRNA expression in the four groups (a,b).

<p>There are significant differences in these levels among the four groups. The COX-2 mRNA expression were significantly higher in the salicylate group than the control group. Compared to the tinnitus group, the <i>Spirulina</i> group (*) or <i>C-PC</i> group (**) exhibits significantly reduced COX-2 mRNA levels in the cochlea and IC.