The six designed chimeras that transfer the active sites of different peptides from <i>Ascaris</i>, Kazal, and potato I family folds.

<p>(A) Amino acid sequence alignments of six chimeras and SjAPI. SjAPI-M1 was from the <i>Ascaris</i>-type peptide AMCI-1, SjAPI-M2 was from the <i>Ascaris</i>-type peptide ATI, SjAPI-M3 was from the <i>Ascaris</i>-type peptide C/E-1, SjAPI-M4 was from the Kazal-type peptide OMTKY3, SjAPI-M5 was from the potato I family peptide CMTI-V, and SjAPI-M6 was from the potato I family peptide CI-2. (B) Comparison of the serine protease inhibitory activity profiles of six chimeras with those of their templates and SjAPI.