Cost-effectiveness analysis.

<p>(A) The graph plots the incremental discounted QALYs (<i>y</i>-axis) and incremental discounted lifetime costs (<i>x</i>-axis) for each combined screening and treatment strategy. The solid line represents the cost-effectiveness frontier, those strategies that are potentially economically efficient depending on one’s willingness-to-pay per unit of health benefit gained. (B) The bar graph shows the incremental cost-effectiveness ratios of each combined screening and treatment strategy at different levels of treatment uptake at each opportunity (varied over the range 0–50%). The asterisk denotes that, at 5% uptake, birth-cohort screening followed by universal triple therapy for screen-detected, treatment-eligible individuals is dominated. For both panels, IL-28B = interleukin-28B; QALY = quality-adjusted life-year.