Heart looping and regional differentiation defects in <i>wnt11r^−/−</i> mutants.

<p>(A) <i>cmlc2</i> ISH showing the looping defect in <i>wnt11r^−/−</i> mutants. (B) Atrio-ventricular axis angle in wild-type (left, green) and <i>wnt11r^−/−</i> mutants (right, blue). N indicates the total number of embryos from 3 experiments. (C) Defective regional differentiation of heart in <i>wnt11r^−/−</i> mutants, similar to those seen in <i>tbx1^−/−</i> mutants. Scale bars: 50 µm.