^PKG1αMSCs promoted angiomyogenesis in the infarct hearts.

<p>(A) Real time PCR showed a significant increase in cardiac transcription factor Nkx2.5, GATA4 and pro-angiogenic factor SDF-1, Ang-1 genes expression in left ventricle tissue at 3 days after transplantation. (B–E) Double immunostaining for troponin I (red) and green fluorescent protein (GFP, green) on histological sections showed transplanted ^PKG1αMSCs differentiated into neofibers more actively as compared to ^nullMSCs at 7 days after transplantation. The nuclei were visualized by staining with DAPI. (E) Fluorescence immunostaining of histological sections from group-2 and group-3 for von Willebrand Factor VIII (green) at 4 weeks after transplantation, blood vessel density was significantly higher in both infarct and peri-infarct regions in group-3 as compared with group-1 and group-2(P<0.01).