<i>Smc5/6</i> mutants are hypersensitive to ionizing radiation.

<p>(A–C) <i>Smc6, MAGE</i> or <i>Smc5</i> homozygous, trans-heterozygous or hemizygous mutants have reduced survival when exposed to 40 Gy of IR. Bars represent the survival index (<i>p</i>) ± SEM. “□” indicates flies eclosed from the same cross. Absence of a bar indicates that no flies survived at that IR dose. (A) <i>Smc6</i> mutants are hypersensitive to IR. <i>R1</i> (<i>jnj^R1</i>) and <i>X1</i> (<i>jnj^X1</i>) are <i>Smc6</i> alleles. <i>Df</i> (<i>Df(3R)Exel6198</i>) is a deficiency chromosome uncovering the <i>Smc6</i> locus. (B) <i>MAGE</i> mutants are hypersensitive to IR. <i>RZ</i> (<i>sst^RZ</i>) and <i>XL</i> (<i>sst^XL</i>) are <i>MAGE</i> alleles. <i>Df</i> (<i>Df(3R)Antp¹</i>) is a deficiency chromosome uncovering the <i>MAGE</i> locus. (C) <i>Smc5</i> mutants are hypersensitive to IR. <i>P5</i> (<i>Smc5^{P{GSV1}GS3245}</i>) and <i>P7</i> (<i>Smc5^{P{GSV6}GS14577}</i>) are <i>Smc5</i> alleles. <i>Df</i> (<i>Df(3L)BSC418</i>) is a deficiency chromosome uncovering the <i>Smc5</i> locus.