Effect of absence of TLR4 on IL-1β and inducible nitric oxide synthase after TBI.

<p>For immunohistological staining for IL-1β and iNOS. Brain sections obtained from TBI-induced WT mice exhibited a positive staining for IL-1β and iNOS (A, D). Absence of TLR4 significantly reduced staining for IL-1β and iNOS (B, E). The figures are representative of at least three experiments performed on different experimental days. Each data are expressed as Mean ± SEM from N = 10 Mice for each group. A <i>p</i>-value of less than 0.05 was considered significant. *<i>p</i><0.01 vs. Sham, °<i>p</i><0.01 vs <i>WT-TBI</i>.