Modest capacity of CD8+ T cells from PHI-patients to suppress infection.

<p><b>A.</b> Capacity of CD8+ T-cells from PHI patients and HIC to suppress HIV infection of autologous CD4+ T-cells ex vivo, measured as the log fall in p24 production in culture supernatants when CD4+ T-cells superinfected in vitro with HIV-1 Bal were co-cultured with unstimulated autologous CD8+ T-cells at a ratio of 1∶1, by comparison with p24 production by superinfected CD4+ T-cells cultured alone. Each symbol represents one patient. Open circles represent patients carrying at least one HLA-B*27 or B*57 allele. <b>B.</b> Correlation between CD8+ T-cell-mediated HIV suppression and the frequency of IFNγ-producing CD8+ T-cells between HIC (black symbols) and PHI patients (red symbols). Linear regression is shown for HIC. <b>C.</b> Capacity of CD8+ T-cells from patients with acute or early PHI to suppress HIV infection ex vivo. <b>D.</b> Comparison of the capacity of CD8+ T-cells from PHI patients with decreasing and stable viral loads to suppress HIV infection of autologous CD4+ T-cells.