Ligand binding of the galectin-8C domain.

<p>The Gal-8C binding site with (<b>A</b>) LacNAc, II, (<b>B</b>) di-LacNAc, (<b>C</b>) Lactose, (<b>D</b>) Lacto-N-neotetrose, (<b>E</b>) BGA, and (<b>F</b>) BGB. Ligands are shown as stick models and the surface of the protein-binding site in violet color. The ligands are color-coded (β-galactose: red; N-acetyl-glucosamine: green; glucose: blue; fucose: cyan; α-galactose and α- N-acetyl-galactosamine: yellow; downstream hydroxy group: white. Hydrogen bonds are shown as yellow dotted line. A snapshot which contains a maximum number of intermolecular hydrogen bonds is displayed. See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0059761#pone.0059761.s007" target="_blank"><b>File S1</b></a> for details of hydrogen bond interactions of each complex. The figure was designed using PyMOL Molecular Graphics System (DeLano Scientific, Palo Alto, CA).