Structural representations with Lopinavir interactions.

<p>(<b>A</b>) Displaying active site of the <i>Pv</i>PM-V Sal-1 (wild type) and its interaction with only known inhibitor lopinavir (red) (<b>B</b>) Displaying active site of the <i>Pv</i>PM-V-Ind (mutant) and its interaction with known inhibitor lopinavir (red). The docked lopinavir (red) showing interaction with hydrophobic amino acid residue (white) of the active site, while hydrophilic residues: acidic (red), Basic (blue) and neutral (green) comprise of the docking site. There are clear overall changes in structure as well as in interacting amino acids with the ligand.