*<p>DNA variant found in the relapse tumor of a LS CRC patient.</p>‡<p>The variants were detected in more than one patient, so we did not describe the characteristics of these patients.</p>†<p>If PolyPhen score >2.0 then the AA substitution is predicted to affect protein function.</p>††<p>If MAPP-MMR score >4.55 then the AA substitution is predicted to affect protein function.</p
BACKGROUND: The human DNA mismatch repair (hMMR) system plays an important role in reducing mutation...
Assessing the pathogenicity of missense mutations of MLH1 and MSH2 is critical to counsel patients w...
Objectives: We studied the role of minor mismatch repair proteins (MMR) human MutL homologue 1 (hMLH...
†<p>The mutation was also found in another blood sample of LS relapsed CRC patient.</p>††<p>One pati...
Research on hMLH1 and hMSH2 mutations tend to focus on Lynch syndrome (LS) and LS-like colorectal ca...
Research on hMLH1 and hMSH2 mutations tend to focus on Lynch syndrome (LS) and LS-like colorectal ca...
Background. Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers...
The DNA mismatch repair (MMR) system is highly conserved and vital for preserving genomic integrity....
Background. Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers...
Background. Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers...
Background. Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers...
SummaryGerm-line mutations in DNA mismatch–repair genes impart a markedly elevated cancer risk, ofte...
Hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome is caused by DNA variations in t...
Colorectal carcinoma (CRC) is one of the most prevalent malignancies in the Czech Republic. In gener...
Background: Loss of DNA mismatch repair (MMR) in humans, mainly due to mutations in the hMLH1 gene, ...
BACKGROUND: The human DNA mismatch repair (hMMR) system plays an important role in reducing mutation...
Assessing the pathogenicity of missense mutations of MLH1 and MSH2 is critical to counsel patients w...
Objectives: We studied the role of minor mismatch repair proteins (MMR) human MutL homologue 1 (hMLH...
†<p>The mutation was also found in another blood sample of LS relapsed CRC patient.</p>††<p>One pati...
Research on hMLH1 and hMSH2 mutations tend to focus on Lynch syndrome (LS) and LS-like colorectal ca...
Research on hMLH1 and hMSH2 mutations tend to focus on Lynch syndrome (LS) and LS-like colorectal ca...
Background. Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers...
The DNA mismatch repair (MMR) system is highly conserved and vital for preserving genomic integrity....
Background. Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers...
Background. Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers...
Background. Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers...
SummaryGerm-line mutations in DNA mismatch–repair genes impart a markedly elevated cancer risk, ofte...
Hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome is caused by DNA variations in t...
Colorectal carcinoma (CRC) is one of the most prevalent malignancies in the Czech Republic. In gener...
Background: Loss of DNA mismatch repair (MMR) in humans, mainly due to mutations in the hMLH1 gene, ...
BACKGROUND: The human DNA mismatch repair (hMMR) system plays an important role in reducing mutation...
Assessing the pathogenicity of missense mutations of MLH1 and MSH2 is critical to counsel patients w...
Objectives: We studied the role of minor mismatch repair proteins (MMR) human MutL homologue 1 (hMLH...