Resting and maximal (+Nifedapine) arteriole diameter at days zero and seven after i.vag. infection in eNOS^-/- mice with TK^-HSV-2 (A).

<p>Representative images of resting and maximal diameter eNOS^-/- arterioles at days zero and seven after infection where arterioles are indicated by green arrows (B). Resting and maximal (+SNP) arteriole diameter at days zero and seven after i.vag. infection with Tk^-HSV-2 in mice treated systemically with L-NAME (C). Resting and maximal vessel diameters (% of uninfected) of WT, eNOS^-/- and L-NAME treated mice. For eNOS^-/- n = 4 and 5 respectively for days zero and seven vessel diameters, and n = 4 for all PE data points (D). For L-NAME treatment, n = 4 for all data points. For WT n = 5 at day seven p.i.. In all cases, one arteriole was studied per animal. *p<0.05, **p<0.01, and ***p<0.001.