PI3Kγ mediated activation of integrin α4β1 requires Rap1a and other co-factors.
- Michael C. Schmid (257851)
- Irene Franco (397208)
- Sang Won Kang (251492)
- Emilio Hirsch (113836)
- Lawrence A. Quilliam (397209)
- Judith A. Varner (129854)
Publication date
April 2013
DOIAbstract
<p>Schematic of stimulated myeloid cells demonstrating that diverse receptor types activate PI3Kγ, thereby promoting integrin α4β1 conformational changes, leading to integrin activation in a PLCγ1, RAP-GEF, Rap1, RIAM, talin and paxillin-dependent manner.</p
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