Effects of various parameters on post-vaccine dynamics are evaluated.

<p>Only one parameter type varies in each figure; other parameters are fixed to the values given in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0059465#pone-0059465-t001" target="_blank">Table 1</a>. (a–d) The rates that B differentiate into plasma cells in the presence of antigen ( and ) are varied together from to /bact/d. (e–f) The number of plasma cells generated by proliferating antigen-activated B () is varied from to pc/mc. The following results are tracked for each parameter: (a,e,f) the peak number of total antibody (lamina propria IgG plus lamina propria and luminal IgA), (b,f,j) the timing of the antibody peak, (c,g,k) the peak number of <i>Shigella</i> in the lumen (L), in the lamina propria (LP), engulfed in innate immune cells (I), and in the epithelium (E), (d,h,l) the timing of the <i>Shigella</i> peak in the aforementioned compartments as well as the time at which the total number of non-epithelial <i>Shigella</i> drops below one bacterium (LLPI Decay). Abbreviations: Ab: antibodies, d: day, bact: bacteria, pc: plasma cells, mc: memory B cells, L: lumen, LP: lamina propria, I: engulfed in innate immune cells, E: epithelium, Log: logarithmic scale, : the number on the x-axis should be used as the exponent of to obtain the true value.