Excessive granulopoiesis is controlled by hyperactive Stat5 in a cell autonomous manner.

<p><b>A</b>. Relative contribution of lymphocytes, monocytes, and granulocytes to the total number of white blood cells (WBCs) and <b>B.</b> total granulocyte counts in healthy and diseased recipients that were engrafted with bone marrow cells from MMTV-tTA TetO-Stat5 <i>Stat5</i>^{Δ<i>N/</i>Δ<i>N</i>} mice and MMTV-tTA TetO-Stat5 <i>Stat5^+/ΔN</i> controls. <b>C.</b> Changes in the number of granulocytes in three diseased recipient mice and controls that were treated for 28 days with Dox. <b>D.</b> Corresponding sections of lung tissues from diseased recipient mice and their normal controls.