Effect of vascular permeability of carriers on the spatial distribution of accumulative exposure.

<p>The effect of vascular permeability of carriers on the spatial distribution of accumulative exposure (in the radial distance, up to ) (MW: 10 kDa, 70 kDa, 2 MDa) in the tumor interstitium. The horizontal lines show the value of AUC equal to 1000 . The diffusion coefficient and plasma half-life time in this case are listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0059135#pone-0059135-t001" target="_blank">Table 1</a> corresponding to each molecular weight.