Serum IgG autoantibodies are detected in all mammals tested.

<p><b>A</b>. Pig, human, and rat brain lysates were separated by SDS-PAGE and then probed with their respective species-specific serum as a primary antibody. Each species possessed IgG autoantibodies that bound to a variety of SDS-denatured brain self-antigens. <b>B</b>. Proteins from pig brain extract were probed with serum collected from a single pig at two timepoints, TP1 and TP2, spanning three months. The majority of the pig auto-reactive IgG antibodies remain the same.