Validation of the modeling prediction regarding the role of peroxisome proliferator-activated receptor (PPAR) γ in regulating the plasticity between T helper (Th) 17 and induced regulatory T cells (iTreg).
- Adria Carbo (120066)
- Raquel Hontecillas (120113)
- Barbara Kronsteiner (120061)
- Monica Viladomiu (120075)
- Mireia Pedragosa (120080)
- Pinyi Lu (120070)
- Casandra W. Philipson (384163)
- Stefan Hoops (129784)
- Madhav Marathe (206059)
- Stephen Eubank (206060)
- Keith Bisset (399375)
- Katherine Wendelsdorf (399376)
- Abdul Jarrah (399377)
- Yongguo Mei (399378)
- Josep Bassaganya-Riera (120051)
Publication date
April 2013
DOIAbstract
<p>(A) Computer simulation illustrating a down-modulation of IL-17, STAT3, RORγt and upregulation of FOXP3 in a differentiated Th17 cell following PPARγ activation. (B) Combination of time-course and PPARγ concentration scan to assess changes of IL-17, STAT3, RORγt and FOXP3 over time. (C) Experimental design for the validation of the model prediction. (D–E) Accumulation of iTreg and Th17 cells in the mesenteric lymph nodes (MLN) and colonic lamina propria (LP) of recipient mice.</p
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