Palladium(II)-Catalyzed Regioselective Arylation of Naphthylamides with Aryl Iodides Utilizing a Quinolinamide Bidentate System
- Lehao Huang (1776796)
- Qian Li (114642)
- Chen Wang (88408)
- Chenze Qi (1776793)
Publication date
April 2013
DOIAbstract
A palladium(II)-catalyzed quinolinamide-directed 8-arylation of 1-naphthylamides with aryl iodides is reported. The bidentate directing group (quinolinamide) proved to be crucial for a highly regioselective transformation. In addition, the amide directing group can be easily hydrolyzed under basic conditions to offer a range of 8-aryl-1-naphthylamine derivatives. The theoretical calculations suggest that the C–H arylation reaction proceeds through a sequential C–H activation/oxidative addition pathway
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